In a small bowl, combine 1 tablespoon salt, 1 tablespoon pepper, 1 tablespoon paprika, 2 teaspoons garlic powder, 1 teaspoon onion powder, 1 teaspoon Italian seasoning, and ¼ teaspoon cayenne pepper.
Rub 2-3 pounds tri-tip with 1 tablespoon olive oil, then sprinkle the rub mixture over the tri-tip and rub it into the meat.
Let the tri-tip sit, covered, at room temperature for 30 minutes.
While the tri-tip is resting, preheat the grill with both direct and indirect heat. Sear the tri-tip on both sides over direct heat, about 5 minutes per side. Then move the tri-tip to a section of the grill with indirect heat. Cook until an instant-read thermometer reads 130 degrees when inserted into the thickest part for medium rare.
Remove the tri-tip from the grill and allow to rest for 10-15 minutes before slicing. Slice the meat against the grain and serve.
Notes
Storage and Make-Ahead Instructions
Leftovers: Cool completely, then store in an airtight container in the fridge for up to 4 days.
Reheat: Reheat leftover tri-tip in the oven at 250 degrees until heated through.
Freezer Meal Option: Rub the tri-tip with the oil and spice mix, then wrap it tightly in plastic wrap. Place in a gallon-sized freezer bag and store in the freezer for up to 3 months. Thaw overnight in the refrigerator, then remove 30 minutes before grilling.
Make Ahead: Rub the tri-tip with the oil and spice mix, then cover with plastic wrap. Store in the fridge for up to 24 hours before grilling. Let it sit at room temperature for 30 minutes before grilling.